At the ESOT Congress 2025, researchers presented a new method for producing functional human islet cells using 3D printing. The technique employs a specially developed bio-ink made from alginate and decellularized human pancreatic tissue. The goal is to create transplantable cellular structures with improved function and extended survival—particularly in comparison to traditional islet cell transplantation.
The study focuses on the bioprinting of islet cells—clusters of cells in the human pancreas responsible for insulin production. The newly developed bio-ink provides a microstructural environment that mimics the natural cellular organization of the pancreas.
“Our goal was to recreate the natural environment of the pancreas so that transplanted cells would survive and function better,” explained lead author Dr. Quentin Perrier. “We used a special bioink that mimics the support structure of the pancreas, giving islets the oxygen and nutrients they need to thrive.”
A key difference from previous transplantation methods lies in the proposed implantation site. While conventional islet cells are usually transplanted into the liver, the researchers suggest a subcutaneous placement under the skin. This approach is less invasive and can be performed under local anesthesia. The cell scaffolds used in this method showed over 90 percent cell survival in vitro and more stable insulin release compared to conventional cell preparations.
Additionally, a porous microarchitecture was implemented to improve permeability for nutrients and oxygen, while also promoting blood vessel formation—critical for the long-term function of the transplanted cells.
“This is one of the first studies to use real human islets instead of animal cells in bioprinting, and the results are incredibly promising,” noted Dr. Perrier. “We’re getting closer to creating an off-the-shelf treatment for diabetes that could one day eliminate the need for insulin injections.”
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