PHC Corporation and Cyfuse Biomedical K.K. have developed a new production technology for regenerative medicine and cell therapy. The collaboration between the two companies has enabled real-time monitoring of the quality of 3D cell constructs containing living cells in three-dimensional structures. This monitoring was previously a challenge and should now enable more stable production of high-quality cell products.
As part of the research, Cyfuse used its proprietary bio-3D printing technology to produce the cell constructs, while PHC developed an inline analysis that tracks the metabolic activity of the cells during cultivation. This combination improves the quality and stability of the cell products by automatically adjusting critical cell growth parameters. PHC’s in-line monitoring technology measures glucose and lactate concentrations in real time and optimizes culture conditions through automated adjustments.
Based on this development, PHC and Cyfuse are planning an advanced recirculating cell culture system that will enable more precise control of the cell condition. The aim is to make manufacturing processes more efficient and further improve product quality. The research results will be presented at the 24th Annual Meeting of the Japanese Society for Regenerative Medicine. The focus will be on the quality assessment of 3D cell constructs and the further development of the circulation system.
Both companies intend to expand their research cooperation and drive forward the practical application of the new production technologies. In addition to the further development of existing systems, PHC and Cyfuse are aiming for strategic expansion within the regenerative medicine value chain. The aim is to use innovative cell culture systems to improve the efficiency and applicability of cell therapies and thus open up new opportunities in medical research and practice.
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