Home Research & Education Tel Aviv University prints personalized thick and perfusable cardiac patches

Tel Aviv University prints personalized thick and perfusable cardiac patches

One challenge of cardiac tissue engineering is the production of thick vascularized tissues that fully match the patient. A new approach to 3D‐print thick, vascularized, and perfusable cardiac patches that match the immunological, cellular, biochemical, and anatomical properties of the patient entirely is reported by researchers of the School for Molecular Cell Biology and Biotechnology of the Tel Aviv University.

In a proof of concept study, the researchers took a biopsy of an omental tissue from patients, reprogrammed the cells to pluripotent stem cells and separated them to cardiomyocytes and endothelial cells to form two bio-inks for the cardiac parenchymal tissue and blood vessels. They printed functional vascularized patches according to the patient’s anatomy and improved the blood vessel architecture further by mathematical modeling the oxygen transfer.

After transplantation they studied the structure and function of the patches in vitro, and assessed the cardiac cell morphology they revealed elongated cardiomyocytes with massive actinin striation. Finally, they printed cellularized human hearts parts with a genetic architecture and demonstrated the potential of the approach. This process could help to engineer personalized tissues and organs, for drug screening in a patient‐specific biochemical microenvironment.

The research team published their findings in the Advanced Science Journal under the title “3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts.”

Source:
Noor, N., Shapira, A., Edri, R., Gal, I., Wertheim, L., & Dvir, T. (2019). 3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts. Advanced Science, 1900344.


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